Soft Tissue Sarcomas: What Every Pathologist Should Know
Soft Tissue Sarcomas: What Every Pathologist Should Know Introduction Soft tissue sarcomas (STSs) represent a diverse and often challenging group of malignant tumors arising from the mesenchymal tissues of the body, including fat, muscle, nerve, fibrous tissue, blood vessels, and deep skin tissues. Although rare—comprising less than 1% of all adult cancers—their wide histological variety and overlapping morphologic features demand a high level of diagnostic precision from pathologists. For pathologists, early and accurate identification of soft tissue sarcomas is essential—not only for guiding clinical management but also for informing prognosis and ensuring appropriate molecular or genetic testing. This blog aims to provide a comprehensive overview of STSs, offering insights into key definitions, diagnostic criteria, anatomic distribution, and the tools essential to differential diagnosis. Whether you're a trainee or an experienced practitioner, understanding the evolving ...